Lajmi se shkenc\u00ebtar\u00ebt amerikan\u00eb kan\u00eb zhvilluar pilula q\u00eb kan\u00eb treguar rezultate t\u00eb r\u00ebnd\u00ebsishme n\u00eb trajtimin e llojeve t\u00eb shumta t\u00eb tumoreve malinje n\u00eb testet paraklinike ka b\u00ebr\u00eb xhiron e bot\u00ebs dit\u00ebt e fundit.<\/p>\n
P\u00ebr k\u00ebt\u00eb flasin dhe shkruajn\u00eb ekspert\u00eb dhe gazetar\u00eb shkencor\u00eb t\u00eb t\u00eb gjitha mediave.<\/p>\n
Vrau t\u00eb gjith\u00eb tumoret e ngurta t\u00eb testuara<\/p>\n
Sipas nj\u00eb punimi t\u00eb botuar n\u00eb Cell Chemical Biology, nj\u00eb nga revistat m\u00eb t\u00eb mira n\u00eb k\u00ebt\u00eb fush\u00eb, shkenc\u00ebtar\u00ebt nga institucioni prestigjioz kalifornian i k\u00ebrkimit t\u00eb kancerit \u2013 City of Hope, treguan n\u00eb nj\u00eb studim paraklinik se nj\u00eb ila\u00e7 i ri kund\u00ebr kancerit vret qelizat e t\u00eb gjith\u00eb tumoreve t\u00eb ngurta t\u00eb testuara, duke l\u00ebn\u00eb qeliza t\u00eb sh\u00ebndetshme, t\u00eb pad\u00ebmtuara.<\/p>\n
Ai synon vet\u00ebm kancerogjen\u00ebt, jo qelizat e sh\u00ebndetshme<\/p>\n
la\u00e7i synon nj\u00eb version kancerogjen t\u00eb protein\u00ebs PCNA q\u00eb m\u00eb par\u00eb konsiderohej \u201ce drogueshme\u201d sepse varianti normal i protein\u00ebs \u00ebsht\u00eb i r\u00ebnd\u00ebsish\u00ebm p\u00ebr shum\u00ebzimin e qelizave t\u00eb sh\u00ebndetshme.<\/p>\n
Aktualisht \u00ebsht\u00eb duke u testuar n\u00eb nj\u00eb num\u00ebr t\u00eb vog\u00ebl pacient\u00ebsh n\u00eb faz\u00ebn e par\u00eb t\u00eb nj\u00eb prove klinike.<\/p>\n
Synimi i t\u00eb paarritshmes<\/p>\n
Ila\u00e7i \u00ebsht\u00eb em\u00ebruar AOH1996 pas vajz\u00ebs s\u00eb vog\u00ebl Anna Olivia Healey, e cila lindi n\u00eb vitin 1996 dhe vdiq nga neuroblastoma n\u00eb mosh\u00ebn 9-vje\u00e7are.<\/p>\n
Profesor Linda Malkas, nj\u00eb shkenc\u00ebtare n\u00eb Departamentin e Diagnostifikimit Molekular dhe Terapis\u00eb Eksperimentale n\u00eb City of Hope, punoi n\u00eb zhvillimin e saj p\u00ebr nj\u00ebzet vjet.<\/p>\n
AOH1996 synon nj\u00eb form\u00eb kancerogjene t\u00eb nj\u00eb proteine \u200b\u200bt\u00eb quajtur antigjen b\u00ebrthamor i qelizave proliferuese (PCNA). PCNA \u00ebsht\u00eb e p\u00ebrfshir\u00eb n\u00eb sintez\u00ebn dhe riparimin e ADN-s\u00eb, por forma e saj kancerogjene (caPCNA) mund t\u00eb stimuloj\u00eb rritjen e qelizave kancerogjene, duke e b\u00ebr\u00eb at\u00eb nj\u00eb objektiv interesant n\u00eb luft\u00ebn kund\u00ebr kancerit.<\/p>\n
\u201cT\u00eb dh\u00ebnat tregojn\u00eb se PCNA \u00ebsht\u00eb ndryshuar n\u00eb m\u00ebnyr\u00eb unike n\u00eb qelizat e kancerit dhe ky fakt na lejoi t\u00eb hartonim nj\u00eb ila\u00e7 q\u00eb synon vet\u00ebm form\u00ebn e PCNA n\u00eb qelizat kancerogjene \u2013 caPCNA. Pilula jon\u00eb \u00ebsht\u00eb si nj\u00eb stuhi d\u00ebbore q\u00eb mbyll nj\u00eb terminal ky\u00e7 t\u00eb aeroportit, duke ndaluar fluturimet e vet\u00ebm atyre avion\u00ebve q\u00eb mbajn\u00eb qeliza kanceroze\u201d, tha Malkas, autori kryesor i studimit t\u00eb ri.<\/p>\n
Pse \u00ebsht\u00eb e r\u00ebnd\u00ebsishme PCNA dhe si funksionon ila\u00e7i?<\/p>\n
Proteina PCNA shum\u00ebfishon ADN-n\u00eb kur dy qeliza formohen nga nj\u00eb qeliz\u00eb, dhe gjithashtu merr pjes\u00eb n\u00eb riparimin e d\u00ebmtimit t\u00eb ADN-s\u00eb.<\/p>\n
Tre proteina PCNA bashkohen dhe rrethojn\u00eb molekul\u00ebn e ADN-s\u00eb si nj\u00eb unaz\u00eb. Pjesa e jashtme e k\u00ebsaj unaze ka vende lidh\u00ebse p\u00ebr proteina t\u00eb tjera, t\u00eb p\u00ebrfshira gjithashtu n\u00eb replikimin dhe riparimin e ADN-s\u00eb.<\/p>\n
Me r\u00ebnd\u00ebsi t\u00eb ve\u00e7ant\u00eb p\u00ebr k\u00ebrkimin e ri \u00ebsht\u00eb konflikti themelor n\u00eb jet\u00ebn qelizore me t\u00eb cilin lidhet PCNA. P\u00ebrkat\u00ebsisht, ADN-ja transkriptohet vazhdimisht n\u00eb ARN, e cila m\u00eb pas p\u00ebrkthehet n\u00eb proteina ose p\u00ebrdoret p\u00ebr q\u00ebllime t\u00eb tjera, dhe n\u00eb k\u00ebt\u00eb marrin pjes\u00eb nj\u00eb num\u00ebr i madh i proteinave dhe proceseve.<\/p>\n
Nga ana tjet\u00ebr, p\u00ebrs\u00ebritja e ADN-s\u00eb e nevojshme p\u00ebr ndarjen e tyre qelizore po zhvillohet vazhdimisht n\u00eb qeliza. Ky \u00ebsht\u00eb nj\u00eb proces krejt\u00ebsisht i ndrysh\u00ebm, i cili gjithashtu p\u00ebrfshin nj\u00eb num\u00ebr t\u00eb madh proteinash q\u00eb rrjedhin posht\u00eb molekul\u00ebs s\u00eb ADN-s\u00eb.<\/p>\n
K\u00ebta dy mekanizma t\u00eb lidhur me ADN-n\u00eb p\u00ebrplasen her\u00eb pas here, q\u00eb quhet p\u00ebrplasje p\u00ebrkthimi-p\u00ebrs\u00ebritjeje.<\/p>\n
Jano\u0161 Terzi\u0107, kreu i laboratorit t\u00eb k\u00ebrkimit t\u00eb kancerit n\u00eb Fakultetin e Mjek\u00ebsis\u00eb n\u00eb Split, thot\u00eb se proteina PCNA \u00ebsht\u00eb b\u00ebr\u00eb objektivi i nj\u00eb ila\u00e7i t\u00eb ri sepse luan nj\u00eb rol t\u00eb r\u00ebnd\u00ebsish\u00ebm n\u00eb zgjidhjen e k\u00ebsaj p\u00ebrplasjeje.<\/p>\n
\u201cGjat\u00eb p\u00ebrplasjes, PCNA nxjerr makinerin\u00eb q\u00eb sintetizon mRNA, dometh\u00ebn\u00eb ARN polimeraza II, e cila p\u00ebrb\u00ebhet nga disa proteina, m\u00eb e madhja prej t\u00eb cilave \u00ebsht\u00eb RPB1. Kur nxjerr ARN polimeraz\u00ebn II, PCNA kontakton RPB1 dhe m\u00eb pas vazhdon me replikimin e ADN-s\u00eb. duket se pas k\u00ebsaj vazhdon edhe sinteza e mARN-s\u00eb, por nuk dihet sakt\u00ebsisht se si.Droga e re, e cila lidhet me kancerogjenin PCNA ose caPCNA, lidh p\u00ebrgjithmon\u00eb caPCNA dhe RPB1, prandaj caPCNA nuk mund t\u00eb vazhdoj\u00eb t\u00eb marr\u00eb pjes\u00eb n\u00eb replikimin e ADN-s\u00eb dhe as nuk mundet. Sinteza e mARN-s\u00eb vazhdon, k\u00ebshtu q\u00eb ADN-ja prishet dhe ndodh d\u00ebmtime t\u00eb tjera t\u00eb ADN-s\u00eb, gj\u00eb q\u00eb \u00ebsht\u00eb fatale p\u00ebr qeliz\u00ebn malinje. Ila\u00e7i nuk funksionon n\u00eb PCNA normale, as n\u00eb qelizat normale, sepse \u00ebsht\u00eb krijuar n\u00eb m\u00ebnyr\u00eb q\u00eb t\u00eb mund t\u00eb lidh vet\u00ebm variantin e caPCNA, \u201c, shpjegoi Terziq.<\/p>\n
Ila\u00e7i \u00ebsht\u00eb treguar i suksessh\u00ebm n\u00eb qeliza dhe kafsh\u00eb<\/p>\n
Shkenc\u00ebtar\u00ebt testuan AOH1996 n\u00eb m\u00eb shum\u00eb se 70 linja qelizore kancerogjene dhe disa qeliza normale t\u00eb kontrollit dhe zbuluan se ai vret n\u00eb m\u00ebnyr\u00eb selektive qelizat e kancerit duke prishur ciklin e tyre normal t\u00eb qelizave riprodhuese. AOH1996 ishte efektiv n\u00eb qelizat e rritura n\u00eb laborator nga nj\u00eb s\u00ebr\u00eb llojesh kanceri, duke p\u00ebrfshir\u00eb kancerin e gjirit, prostat\u00ebs, trurit, vezoreve dhe mushk\u00ebrive.<\/p>\n
Hulumtimet kan\u00eb treguar se AOH1996 synon p\u00ebrplasjen e lartp\u00ebrmendur midis transkriptimit dhe replikimit.<\/p>\n
\u201cAskush nuk e ka sh\u00ebnjestruar m\u00eb par\u00eb PCNA si nj\u00eb objektiv terapeutik sepse mendohej se ishte \u2018i droguesh\u00ebm\u2019, por City of Hope ka pasur sukses n\u00eb zhvillimin e nj\u00eb ila\u00e7i hetimor p\u00ebr nj\u00eb objektiv sfidues t\u00eb proteinave,\u201d tha Dr. Long Gu, bashk\u00ebautor i studimit. dhe asistent profesor n\u00eb City of Hope.<\/p>\n
\u201cNe zbuluam se PCNA \u00ebsht\u00eb nj\u00eb nga shkaqet e mundshme t\u00eb rritjes s\u00eb gabimeve t\u00eb replikimit t\u00eb acidit nukleik n\u00eb qelizat kancerogjene. Tani q\u00eb e njohim zon\u00ebn e problemit dhe mund ta frenojm\u00eb at\u00eb, ne do ta hetojm\u00eb \u00e7\u00ebshtjen m\u00eb thell\u00eb p\u00ebr t\u00eb kuptuar procesin dhe p\u00ebr t\u00eb zhvilluar kancerin e personalizuar dhe t\u00eb drog\u00eb\u201d, shtoi ai.<\/p>\n
P\u00ebrmir\u00ebson trajtimin me barna t\u00eb tjera<\/p>\n
Hulumtimet nga i nj\u00ebjti ekip treguan gjithashtu se ila\u00e7i i ri rrit ndjeshm\u00ebrin\u00eb e qelizave t\u00eb kancerit ndaj cisplatin\u00ebs, nj\u00eb ila\u00e7 i p\u00ebrdorur gjer\u00ebsisht p\u00ebr kimioterapin\u00eb. Agjent\u00ebt kimik\u00eb si cisplatina d\u00ebmtojn\u00eb ADN-n\u00eb ose kromozomet, duke treguar se AOH1996 mund t\u00eb jet\u00eb shum\u00eb efektiv n\u00eb kombinim me terapi t\u00eb tjera dhe t\u00eb r\u00ebnd\u00ebsish\u00ebm p\u00ebr zhvillimin e agjent\u00ebve t\u00eb rinj t\u00eb kimioterapis\u00eb.<\/p>\n
Trajtimi reduktoi ndjesh\u00ebm tumoret dhe rriti mbijetes\u00ebn<\/p>\n
Studimet n\u00eb minj t\u00eb implantuar me tumore q\u00eb rrjedhin nga qelizat e neuroblastom\u00ebs njer\u00ebzore, kanceri i gjirit ose kanceri i mushk\u00ebrive me qeliza t\u00eb vogla treguan gjithashtu se trajtimi me AOH1996 uli ndjesh\u00ebm ngarkes\u00ebn e tumorit n\u00eb krahasim me grupet e kontrollit.<\/p>\n
P\u00ebr m\u00eb tep\u00ebr, kombinimi i AOH1996 me nj\u00eb ila\u00e7 tjet\u00ebr t\u00eb p\u00ebrdorur gjer\u00ebsisht p\u00ebr kancerin, irinotecan, rriti ndjesh\u00ebm mbijetes\u00ebn e minjve t\u00eb transplantuar me tumore njer\u00ebzore n\u00eb krahasim me minjt\u00eb e trajtuar vet\u00ebm me secilin ila\u00e7.<\/p>\n
Prova e par\u00eb klinike tek njer\u00ebzit<\/p>\n
N\u00eb k\u00ebrkime t\u00eb m\u00ebtejshme, shkenc\u00ebtar\u00ebt e City of Hope planifikojn\u00eb t\u00eb hetojn\u00eb mekanizmin e veprimit t\u00eb AOH1996 p\u00ebr t\u00eb kuptuar m\u00eb mir\u00eb ila\u00e7in dhe p\u00ebr t\u00eb p\u00ebrmir\u00ebsuar provat klinike ekzistuese.<\/p>\n
\u201cKy studim raporton aktivitetin antikancerogjen t\u00eb AOH1996 n\u00eb nj\u00eb gam\u00eb t\u00eb gjer\u00eb t\u00eb qelizave kancerogjene dhe n\u00eb disa modele t\u00eb tumorit t\u00eb kafsh\u00ebve,\u201d shkruajn\u00eb autor\u00ebt n\u00eb punim.<\/p>\n
\u201cNe e pranojm\u00eb se rezultatet pozitive n\u00eb studimet e kafsh\u00ebve nuk p\u00ebrkthehen gjithmon\u00eb n\u00eb sukses n\u00eb trajtimin e kancerit njer\u00ebzor. Prova t\u00eb m\u00ebtejshme klinike jan\u00eb t\u00eb nevojshme p\u00ebr t\u00eb p\u00ebrcaktuar efektivitetin e tij tek njer\u00ebzit,\u201d shtuan ata.<\/p>\n
\u00c7far\u00eb zbulon faza e par\u00eb e provave klinike?<\/p>\n
\u0110iki\u0107 thot\u00eb se n\u00eb faz\u00ebn e par\u00eb klinike m\u00eb e r\u00ebnd\u00ebsishme \u00ebsht\u00eb t\u00eb p\u00ebrcaktohet se si dozohet dhe u jepet ila\u00e7i pacient\u00ebve dhe n\u00ebse ka ndonj\u00eb efekt negativ.<\/p>\n
\u201c\u00cbsht\u00eb nj\u00eb faz\u00eb shum\u00eb kritike. Dometh\u00ebn\u00eb, t\u00eb dh\u00ebnat nga modelet e kafsh\u00ebve jan\u00eb t\u00eb r\u00ebnd\u00ebsishme, por testi kryesor \u00ebsht\u00eb ende testimi i barnave t\u00eb reja n\u00eb studimet klinike te njer\u00ebzit\u201d, tha Gjikiq, duke theksuar se n\u00eb k\u00ebt\u00eb moment \u00ebsht\u00eb mosmir\u00ebnjoh\u00ebse t\u00eb flitet p\u00ebr probabiliteti q\u00eb ila\u00e7i do t\u00eb jet\u00eb efektiv tek njer\u00ebzit.<\/p>\n","protected":false},"excerpt":{"rendered":"
Lajmi se shkenc\u00ebtar\u00ebt amerikan\u00eb kan\u00eb zhvilluar pilula q\u00eb kan\u00eb treguar rezultate t\u00eb r\u00ebnd\u00ebsishme n\u00eb trajtimin e llojeve t\u00eb shumta t\u00eb tumoreve malinje n\u00eb testet paraklinike<\/p>\n","protected":false},"author":14,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[],"class_list":["post-13737","post","type-post","status-publish","format-standard","hentry","category-kuriozitete"],"_links":{"self":[{"href":"https:\/\/indeks.bilten.mk\/index.php?rest_route=\/wp\/v2\/posts\/13737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/indeks.bilten.mk\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/indeks.bilten.mk\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/indeks.bilten.mk\/index.php?rest_route=\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/indeks.bilten.mk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13737"}],"version-history":[{"count":0,"href":"https:\/\/indeks.bilten.mk\/index.php?rest_route=\/wp\/v2\/posts\/13737\/revisions"}],"wp:attachment":[{"href":"https:\/\/indeks.bilten.mk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13737"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/indeks.bilten.mk\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13737"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/indeks.bilten.mk\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}